A mechanistic in-vitro animal study on the effects of caffeine on fertility was recently published in the British Journal of Pharmacology.1
The study has no practical relevance to human health as concentrations of caffeine given to mice were extremely high, with the lowest dose equivalent to consuming approximately 50 cups of coffee, and therefore not comparable with normal and moderate coffee consumption. The results should therefore not be extrapolated to recommendations for women and their fertility outcomes.
Overall there is little evidence to link caffeine with fertility issues. What evidence there is remains insufficient to provide any pre-conception coffee consumption advice.2
